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Re: [RC] [RC] CPK - Elizabeth Chase

Hopefully this is a quick question.... my understanding of CPK levels (in
humans anyway) is that it may also reflect intense exertion, not only damage.
The damage occurs after the lysed muscle cells release their proteins, which
are very large and the kidneys have difficulty clearing them effectively if
overloaded, thus causing rhabdomyelosis. Additional numbers, like GFR,
creatinine clearance, ammonia, and lactic acid among others aids the diagnosis
and therapy. In an otherwise healthy patient, IV fluid rescusitation is usually
indicated. Occasionally someone may require dialysis. Troponin levels target
cardiac damage specifically (for the lay reader, of course you know this Dr.
Q).

Is this similar in horses?

Oh, and would you or someone please recommend a book or additional resources
addressing equine metabolism? My Delphi may be insulin resistant, and we are
copng with an episode of laminitis. I have the large text entitled Lameness .


Trying to learn,

LizC
MN 


--- ridecamp-owner@xxxxxxxxxxxxxxxxx <bweary@xxxxxxxxxxxx> wrote:

  Kathy--
  CPK stands for creatine phosphokinase, and it is an enzyme that is 
released when muscle cells are damaged. In horses, it is expectedly high 
after tying-up. In people it can be used to diagnose heart attack due to 
damaged muscle cells in the heart. Hope your horse recovers soon.  Dr Q

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