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RE: [RC] [RC] Flaxen, Sabino gene - heidi

I've been sitting out this discussion, but wanted to
jump in and say that Kris is making a good point here.
 Sabino does not breed like a single-gene trait.  It
*may* be an "on/off" switch (like the Lp gene in
appaloosas) with additional modifiers controlling the
degree and type of expression, or it *may* be a
polygenic trait with no main "on/off" gene.  In other
words, because of the way sabino breeds and the wild
variance in expression, it's probably incorrect to
talk about a "sabino gene."  It's a pattern that is
likely controlled by multiple genes.  


Thanks for jumping in here, Nicole.  I've not had time to comment,
either.  Equine geneticists are fairly certain that the sabino trait is
NOT due to a single gene, but rather is polygenic.  You list some of the
possible combinations.  In any event, the inheritance mode for sabino is
NOT worked out, and the fact that it is not likely to be a single gene
is about all that one can truthfully say about it.  So talking about a
"sabino gene" is not accurate.

Heidi


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