Endurance.Net Ridecamp Archives

I'm still not really clear on what Adequan and Legend are.  I have the
impression that they are injections of fluid into the joint itself, used to
lubricate it.  I'll look it up though.

Barb, it does seem as if you are correct about RVI being an immune suppressant,
but it seems to only target the cells that are overactive anyway... bringing
the immune response of those particular overactive cells down to normal levels
(not below normal like steroids seem to) so that the immune system will act the
way it's *supposed* to.

> From the site:
********
"John McMichael, Ph.D., an immunologist whose pioneering work led to the
development of RVI... theorized the mechanism might involve some sort of immune
system signaling ? that the medication acts on a specific site on the suppressor
T-cells to trigger, in a controlled fashion, their correct activity. The
hypothesis is that the result is the re-establishment of the normal balance
between various subpopulations of T-and B- lymphocytes, which would aid in the
healing process and lead to a decrease or elimination of myofascial
inflammation and pain in afflicted animals. "The problem is addressed at its
source," he states.

Microbiologist Ellis Kline, Ph.D., who helped develop RVI, has been conducting
continuing research on this therapeutic agent with his laboratory team in South
Carolina. He notes that RVI?s effect on inflammation differs from other
anti-inflammatories. "Steroid therapy shuts down the immune response, leaving
the body?s systems vulnerable to other threats," he explains, "and pain
relievers primarily suppress symptoms."

According to Kline, the precise mechanism by which RVI works is still not
completely known. But it appears that RVI?s selectivity involves only those
parts of the system causing the inflammation. It allows other defenses to
remain normal and "ready" without blanketing the system or masking symptoms."
********

I, too, will be interested to hear responses from Bruce and any vets on the
list.

-Sharon L.



Quoting Barb Peck <bpeck9191@xxxxxxxxxxxx>:

> Sharon:
>
>     I wouldn't put  RVI in the same category as HA (hyalauronic acid) or
> Adequan (PSGAGS).
>
> RVI is an immune modulator  (a modulator can either stimulate or suppress the
> immune system).
>
> Read your site again.... RVI acts upon the cells of the immune system.. looks
> like a immunosuppressant to me,
> (T-cell suppressor ) just a different agent/mechanism as the steroids used in
> autoimmune disorders and probably  JUST as illegal as corticoid steroids in
> competition.
>
> Maybe Bruce can comment on this.
>
> Barb
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