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[RC] Ulcers/fat - Ridecamp Guest

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Effects of dietary oils on the development of gastric ulcers in mares
Nicholas Frank, DVM, PhD; Frank M. Andrews, DVM, MS; Sarah B. Elliott, BS; John 
Lew, PhD *



Abstract
Objective?To assess antiulcerogenic properties of 3 dietary oils.

Animals?8 healthy adult mares.

Procedure?A protocol to induce gastric ulcers was used and included 240 mL of 
water plus corn oil, refined rice bran oil, or crude rice bran oil administered 
each day for 6 weeks according to a 4 × 4 Latin square randomized crossover 
design with 5-week washout intervals. A 7-day alternating feed deprivation 
period was included between weeks 5 and 6. Omeprazole was administered daily 
for the last 14 days of each washout interval. Endoscopic examinations of the 
stomach were performed at 0, 5, and 6 weeks, and the number (0 to 4 scale) and 
severity (0 to 5 scale) of ulcers were scored. Gastric fluid was collected at 0 
and 5 weeks.

Results?Median body weight significantly increased by 29 kg (range, 10 to 50 
kg). Mean ± SE gastric fluid pH significantly decreased from 4.9 ± 0.4 to 3.1 ± 
0.3 over 5 weeks, and total volatile fatty acid concentration significantly 
decreased over time. Mean ± SE severity of nonglandular ulcers significantly 
increased from 0.4 ± 0.1 to 1.2 ± 0.2 over 5 weeks. Nonglandular ulcers 
significantly increased in number (mean ± SE, 1.3 ± 0.2 to 3.0 ± 0.2) and 
severity (mean ± SE, 1.2 ± 0.2 to 2.6 ± 0.2) during the 7-day alternating feed 
deprivation period. No effects of treatment were detected.

Conclusions and Clinical Relevance?In this model dietary oils did not prevent 
gastric ulcers from forming in the nonglandular portion of the stomach of 
horses.




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