Re: [RC] Preventing Treatment - Next Steps - Stagg_NewmanSue, Great idea! Will catalog all ideas and we can discuss in Chattanooga. You now have me really thinking. We have a 17 year old endurance horse, Smoke Rise Strut, that has a wierd skin condition (looks like what one would get with sarcodosis but thus far no indication of internal organ damange). It seems to be an auto-immune response to his own skin. Has been going on for several years now and progressing. This week we are taking him to U. of Ga. to see Dr. Susan White for the 3rd time. She will do a "head to tail" scan, etc. to see what we can learn. In his career he did about 15 1-day 100s, almost all top ten with a couple of wins and lots of top 5. He was however prone to deyhydration and the thumps. Wonder now if any cause and effect. We certainly need to learn more about what we are doing to these horses. Another interesting observation. After the world championships in France we observed the French team had all of their horses on IV fluids to rehydrate them before shipping. (This was legal as is was more that that the required time for no treatment after the ride). Probably smart prevention particularly before flying home. Stagg Newman Senior Practice Expert America's Telecom Practice McKinsey and Company 1-828-232-1314 "Susan Garlinghouse" To: <ridecamp@xxxxxxxxxxxxx>, <Stagg_Newman@xxxxxxxxxxxx> <suendavid@worldn cc: et.att.net> Subject: Re: [RC] Preventing Treatment - Next Steps 02/23/2003 09:22 PM 2. There were some great suggestions on data that could be collected and the data. Would anybody be willing to take the first cut at compiling a list of suggested studies? Sue or Heidi? Others? This would be my Big Numero Uno suggested study: 1. Identifying the long term effects of repeated bouts of dehydration. We already know with peer-reviewed data that the average endurance horse finishes a ride around 5% dehydrated (and some up to 12%), and that cellular function begins to be adversely affected around 3-4%. Assuming no major metabolic breakdowns, the target organ most likely to suffer permanent damge is the kidney. There are some blood parameters that are indicative of kidney damage, but mostly just indicate some current level of dehydration, or severe kidney disease---not early damage. The best ways to measure true kidney function are either by serial urine samples throughout the ride, along with blood samples; or injecting a harmless substance into the body and measuring over the next hour or two how fast the kidneys are able to filter it out. (Or you can do a kidney biopsy, but that's really high risk and not worth even considering). The former protocol of collecting urine is pretty easy, but involves A LOT of rider cooperation, since horses don't always conveniently pee in a vet check while a volunteer is waiting there. So there's the rub---this is incredibly valuable data, but what would it take for an endurance rider to agree to do whatever it takes to collect several urine samples throughout a ride? Money? A ride made up only of research participants as is the Middleburg Research Ride (this would be my guess)? Whatever it takes, IMO, this Susan G +---------------------------------------------------------+ This message may contain confidential and/or privileged information. If you are not the addressee or authorized to receive this for the addressee, you must not use, copy, disclose or take any action based on this message or any information herein. If you have received this message in error, please advise the sender immediately by reply e-mail and delete this message. Thank you for your cooperation. +---------------------------------------------------------+ =-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-= Ridecamp is a service of Endurance Net, http://www.endurance.net. Information, Policy, Disclaimer: http://www.endurance.net/Ridecamp Subscribe/Unsubscribe http://www.endurance.net/ridecamp/logon.asp Ride Long and Ride Safe!! =-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=
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