Re: Re: tie ups and carbs

["Duncan Fletcher" <dfletche@gte.net>]

There was an article a couple of months back in Equus covering tie-up due to
calcium metabolism and tie-up due to polysacharide storage problems. Both
have a probably inheritance correlation (in entirely different breeds of
horses). The studies indicate to me that tie-up are series of different
problems with the same manifestation. Neither of these studies indicate Se
as a problem (or solution) to tie-ups - in fact I am still looking for any
research in support of that - which would be different that either of the
above. If that is the case, while it is possible that a single solution may
be beneficial in aleviating that manifestation, the underlying solution will
be different depending on the cause. What in the hell is there about
chromium that relates to either calcium metabolism or selenium deficiency
(assuming that plays a role in some tieups). If I understand Tom, chromium
causes a more rapid uptake of glycogen in the cell - or have I screwed this
up. But the diet recommended for the PSS horses in low carb. How would rapid
uptake of glycogen correct that problem. Damn it - don't have the article on
PSS in front of me.

Duncan Fletcher
dfletche@gte.net


----- Original Message -----
From: <CMKSAGEHIL@aol.com>
>
> Also depends on the horse.  Tie-ups on alfalfa are generally due to
calcium
> problems.  The calcium in the alfalfa causes the horse to not produce very
> much calcitonin--the hormone that regulates blood calcium.  Then when he
gets
> in a situation where he needs to mobilize calcium--such as heavy
exercise--he
> can't.  Some horses can deal with this better than others--we see horses
here
> on identical diets of local alfalfa mixed with local grass (and our Oregon
> alfalfa is not overly rich)--some can't tolerate it at all, and will tie
up,
> and others will go merrily on their way with nary a problem.  We also have
> one who can't tolerate it--we didn't have him on any last year, and he was
> fine, but he missed a couple of races here after tying up on a training
ride.
>  Interesting to me was the difference in his post-tie-up recovery curve
vs.
> horses I've seen ridden past the ragged edge at rides--this guy had HIGH
CPK
> and SGOT but cleared both in less than a week, whereas I've seen many with
> similar profiles that were ridden "past the edge" so to speak that took
> several weeks to reach a normal profile.  At any rate, no more alfalfa--no
> more problem.  He can eat it just fine when not working (and is on it for
> winter) but he will darn sure come back off of it as soon as he goes back
to
> work.
>
> BTW--the genetics group at UC Davis is doing some work on the heritability
of
> tying up, and I would suspect that there is a strong heritability among
those
> who have calcium regulation problems--this guy is related to several top
> endurance horses who have to have careful calcium management, but more of
> them have manifested it by thumping when out of whack rather than by tying
up.
>
> Heidi
>




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