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[RC] CHO/cortisol - Ridecamp Guest

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Authors DC Nieman, JM Davis, DA Henson, SJ Gross, CL Dumke, AC Utter, DM Vinci, 
JA Carson, A Brown, SR McAnulty, LS McAnulty, NT Triplett
Title   Muscle cytokine mRNA changes after 2.5 h of cycling: Influence of 
carbohydrate
Full source     Medicine and Science in Sports and Exercise, 2005, Vol 37, Iss 
8, pp 1283-1290

Purpose: To study the effect of carbohydrate compared to placebo ingestion on 
plasma cytokines and muscle cytokine mRNA following 2.5 h of intensive cycling 
in 15 trained cyclists. Methods: Fifteen trained cyclists cycled for 2.5 h at 
60% W-max on two occasions while receiving 4 mL(.)kg(-1.)15 min(-1) 
carbohydrate (6%) (CHO) or placebo (PLA) beverages in a randomized, 
counterbalanced design. Blood and vastus lateralis muscle biopsy samples were 
collected before and after exercise and 12 h postexercise and compared to 
samples taken from five cyclists who rested in the lab during the exercise 
sessions. Blood cell counts were determined, and plasma was analyzed for 
interleukin (IL)-6, IL-10, IL-1 receptor antagonist (ra), IL-8, cortisol, 
epinephrine, glucose, and insulin. Muscle was analyzed for glycogen content and 
relative gene expression of four cytokines, IL-6, IL-8, tumor necrosis factor 
(TNF) alpha, and IL-10, using real-time quantitative reverse transcriptase 
polymerase chain reaction. Results: Plasma glucose and insulin were higher, and 
epinephrine, cortisol, IL-6, IL-10, and IL-Ira, but not IL-8, were 
significantly lower postexercise in CHO versus PLA. Muscle glycogen content 
decreased 68% immediately postexercise and the pattern of change did not differ 
between CHO and PLA. Muscle IL-6, IL-9, TNF-alpha, but not IL-1 beta mRNA 
increased immediately postexercise compared to controls, with no differences 
between CHO and PLA. Conclusion: CHO compared to PLA beverage ingestion 
attenuated the increase in plasma cortisol, epinephrine, IL-6, IL-10, and 
IL-Ira, but not muscle IL-6, IL-8, and TNF-alpha mRNA in athletes cycling 2.5 h 
at 60% W-max.


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