Ridecamp: [RC] re: : [RC] Fungus Among Us

Hi Stephanie -

You might ask your vet about Fulvicin.  It's a feed through that you get by
perscription, not super expensive, and as the hair grows out on your horse,
it gets anti-fungal protection from the Fulvicin.  We used it along with
bathing for a bad ringworm case on a horse.  See the stuff pasted below my
sig line for a more complete description of griseofulvin (Fulvicin).

Happy trails -
Michelle
(Colorado)

from http://www.doctorfungus.org

Griseofulvin

Trade & Generic Names & General Features

Griseofulvin is an antifungal agent first isolated from a Penicillium spp.
in 1939. The compound is insoluble in water. It is effective after oral
ingestion and reaches the skin and hair. It is deposited primarily in
keratin precursor cells. Ingestion with a heavy meal and reduction in
particle size enhances the absorption of griseofulvin [1193].

Griseofulvin is currently produced by a number of different companies. It is
available in two different forms. The microcrystalline form of griseofulvin
is marketed as Fulvicin U/FT (Schering), Grifulvin VT (Ortho
Dermatological), and GrisactinT (Wyeth-Ayerst). The trade names of
ultramicrocrystalline form are Fulvicin P/GT (Schering), Gris-PEGT
(Allergan), and Grisactin UltraT (Wyeth-Ayerst).


Mechanism(s) of Action

Griseofulvin inhibits fungal mitosis by disrupting the mitotic spindle
through interaction with polymerized microtubules [827].


Susceptibility Patterns

Griseofulvin is mainly effective on a specific group of fungi,
dermatophytes. However, a standardized in vitro susceptibility testing
methodology is not yet available for this group of fungi. Studies to address
this to question are in progress. One of the parameters under investigation
is the standard medium to be used in the test [990]. This medium should
enhance conidium formation in dermatophytes.

Although as yet unstandardized, the in vitro activity of griseofulvin has
been tested against various dermatophytes. The major goal of performing
susceptibility tests for griseofulvin is to compare its in vitro activity
with those of novel agents used in treatment of dermatophytosis.
Griseofulvin yields higher MICs compared to terbinafine and itraconazole
when tested against Trichophyton rubrum isolates [990, 1092]. It is also
less active than voriconazole against most dermatophytes [2160]. The reduced
in vitro activity of griseofulvin against Trichophyton mentagrophytes
compared to Trichophyton rubrum is also noteworthy [1092]. However, the
meaning and clinical significance of these data demand further
investigations and development of a standard in vitro susceptibility testing
method.

For griseofulvin MICs obtained for various types of fungi, see
susceptibility patterns and the susceptibility database.


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