article on Panacur

["Carolyn Burgess" <carolyn_burgess@hotmail.com>]

This came from another ridecamp reader and is excellent to share.  We have 
been going back and forth about toxicity of wormers and are getting 
differing information about it.

Carolyn Burgess



>     Fenbendazole given orally at a dose of 10mg/kg daily for five days has 
>the
>     broadest spectrum of activity against parasitic stages of the small
>     strongyles. It is generally recommended that larvicidal doses of
>     Fenbendazole should be incorporated into parasite control programs at 
>least
>     once and possibly twice during the calendar year. The single yearly
>     treatment is usually given in November or December and the twice 
>yearly
>     treatments are recommended for April and October. The problem of
>     anthelmintic resistance among the small strongyles is particularly
>     prevalent in the benzimidazoles. Oxibendazole and larvicidal doses of
>     Fenbendazole are effective against adult small strongyles but 
>veterinarians
>     and horse-owners should be particularly vigilant for the emergence of
>     anthelmintic resistance to these two drugs. The use of larvicidal 
>doses of
>     Fenbendazole is becoming popular and this increased use could hasten 
>the
>     emergence of drug resistance.
>
>     Benzimidazoles
>     ·       Relative safety
>     ·       Therapeutic index ranges: (taken for horses)
>     ivermectin 10
>     moxidectin 5
>     thiabendazole 13
>     mebendazole 45
>     fenbendazole 200
>     oxfendazole 10
>     oxibendazole 60
>     trichlorfon 1
>
>

_________________________________________________________________
Get your FREE download of MSN Explorer at http://explorer.msn.com