Water Intake/NSAIDS

["Nikki & Shannon" <jakar@phonewave.net>]

To further expand on this subject, there is also an article in the May 2000
issue of Trail Runner magazine, (Vitamin I?, pg. 24), written by Shelley
Downing, that says NSAIDS, particularly Ibuprophen, can interfere with the
body's fluid and electrolyte balance.  NSAIDS inhibit the production of the
hormone prostaglandin, which is responsible for keeping the vessels of the
kidneys open and regulating blood flow there.  Dehydration in itself can
lead to kidney failure... add prostaglandin inhibition... and you've set up
a potentially disastrous equation.  Several physicians and studies have come
to the conclusion that taking NSAIDS before, during, or during recovery from
a long run isn't a good idea.

Ibuprophen was cited specifically for causing stomach and intestinal
problems as well.  A study published in the Journal of Sport Nutrition has
concluded that ibuprophen increases gastrointestinal permeability.  That
means there is more fluid and blood loss in the stomach and intestines.
Overdoses can lead to sloughing of the membranes of the gastrointestinal
tract.  In one case mentioned, a woman was taken directly to the hospital
and diagnosed with rhabdomyolsis (tying up syndrome?!) after taking 12
ibuprophen during a 24-hour ultra.  She was pumped with fluids until her
kidneys responded.

I can also see how this ties in with the post Kat sent earlier on giving
NSAIDS to horses and the resulting decreased peristalic action of the gut as
well.

Nikki
Fallon, NV



-----Original Message-----
From: Denise Krakowski [mailto:denisek@mail.wsu.edu]
Sent: Tuesday, May 09, 2000 11:33 AM
To: ridecamp@endurance.net
Subject: RC: Water Intake

<snip>
 And, Ayus pointed out, all seven had a
history of using nonsteroidal anti-inflammatory
drugs--painkillers that include aspirin. These drugs can
block the excretion of water from the body, he explained
<snip>