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Reproductive effects: Intraperitoneal and subcutaneous in rat caused testes,
sperm abnormalities, sperm duct abnormalities, at 7500 ug/kg-3192 ug/kg
Fetotoxicity (except death) -developmental abnormalities, central nervous
system, cardiovascular system abnormalities in mouse at 3200ug/kg
Post implantation moratality- iv in mouse 3200ug/kg
Biochemical and metabolic effects in pigs- oral dose 140mg/kg
Post implantation mortality , developmental abnormalities, central nervous
system abnormalities, iv in hamster at 2130 ug/kg
Tumorigenic effects: nausea or vomiting -oral in humans at 857mg/kg
Other hemolysis with or without anemia -oral in children 150mg/kg
Somnolence and general depressed activity, hemorrhage in human oral at 50mg/kg
Gastritis , hypermotility, diarrhea, nausea, vomiting in human ral at 11mg/kg
Convulsions or effect on seizure threshold in rat intraperitoneal at 20mg.kg
Convulsions or effect on seizure threshold , food intake, hypermotility,
diarrhea in rabbit iv 10mg/kg. Same effects in guinea pig iv at 2mg/kg
Other multiple dose effects: Changes in coronary arteries, serum composition
in rat oral 915mg/kg for 1 year.
Changes in adrenal weight, weight loss, or decreased weight gain oral in rat
157mg/kg for 6 weeks.
Changes in serum composition, erythrocyes count, multiple enzyme effects oral
in rat at 7530mg/kg for 30 days
Liver-other changes, phosphotases, other enzymes - rat oral at 2gm/kg for 20
days
Spleen, decrease in immune response at 2gm/kg in mouse
EPA, NIOSH,NTP status- EPA genetox program 1988-positive as a cell transformer
EPA Toxic Substances Control Act
-Amy
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